This paper proposes a question-answering system that can answer questions whose supporting evidence is spread over multiple (potentially long) documents. The system, called Visconde, uses a three-step pipeline to perform the task: decompose, retrieve, and aggregate. The first step decomposes the question into simpler questions using a few-shot large language model (LLM). Then, a state-of-the-art search engine is used to retrieve candidate passages from a large collection for each decomposed question. In the final step, we use the LLM in a few-shot setting to aggregate the contents of the passages into the final answer. The system is evaluated on three datasets: IIRC, Qasper, and StrategyQA. Results suggest that current retrievers are the main bottleneck and that readers are already performing at the human level as long as relevant passages are provided. The system is also shown to be more effective when the model is induced to give explanations before answering a question. Code is available at \url{https://github.com/neuralmind-ai/visconde}.

Candidate axiom scoring is the task of assessing the acceptability of a candidate axiom against the evidence provided by known facts or data. The ability to score candidate axioms reliably is required for automated schema or ontology induction, but it can also be valuable for ontology and/or knowledge graph validation. Accurate axiom scoring heuristics are often computationally expensive, which is an issue if you wish to use them in iterative search techniques like level-wise generate-and-test or evolutionary algorithms, which require scoring a large number of candidate axioms. We address the problem of developing a predictive model as a substitute for reasoning that predicts the possibility score of candidate class axioms and is quick enough to be employed in such situations. We use a semantic similarity measure taken from an ontology's subsumption structure for this purpose. We show that the approach provided in this work can accurately learn the possibility scores of candidate OWL class axioms and that it can do so for a variety of OWL class axioms.

Heteroscedastic regression models a Gaussian variable's mean and variance as a function of covariates. Parametric methods that employ neural networks for these parameter maps can capture complex relationships in the data. Yet, optimizing network parameters via log likelihood gradients can yield suboptimal mean and uncalibrated variance estimates. Current solutions side-step this optimization problem with surrogate objectives or Bayesian treatments. Instead, we make two simple modifications to optimization. Notably, their combination produces a heteroscedastic model with mean estimates that are provably as accurate as those from its homoscedastic counterpart (i.e.~fitting the mean under squared error loss). For a wide variety of network and task complexities, we find that mean estimates from existing heteroscedastic solutions can be significantly less accurate than those from an equivalently expressive mean-only model. Our approach provably retains the accuracy of an equally flexible mean-only model while also offering best-in-class variance calibration. Lastly, we show how to leverage our method to recover the underlying heteroscedastic noise variance.

Computational pathology can lead to saving human lives, but models are annotation hungry and pathology images are notoriously expensive to annotate. Self-supervised learning has shown to be an effective method for utilizing unlabeled data, and its application to pathology could greatly benefit its downstream tasks. Yet, there are no principled studies that compare SSL methods and discuss how to adapt them for pathology. To address this need, we execute the largest-scale study of SSL pre-training on pathology image data, to date. Our study is conducted using 4 representative SSL methods on diverse downstream tasks. We establish that large-scale domain-aligned pre-training in pathology consistently out-performs ImageNet pre-training in standard SSL settings such as linear and fine-tuning evaluations, as well as in low-label regimes. Moreover, we propose a set of domain-specific techniques that we experimentally show leads to a performance boost. Lastly, for the first time, we apply SSL to the challenging task of nuclei instance segmentation and show large and consistent performance improvements under diverse settings.

Identifying anomalies has become one of the primary strategies towards security and protection procedures in computer networks. In this context, machine learning-based methods emerge as an elegant solution to identify such scenarios and learn irrelevant information so that a reduction in the identification time and possible gain in accuracy can be obtained. This paper proposes a novel feature selection approach called Finite Element Machines for Feature Selection (FEMa-FS), which uses the framework of finite elements to identify the most relevant information from a given dataset. Although FEMa-FS can be applied to any application domain, it has been evaluated in the context of anomaly detection in computer networks. The outcomes over two datasets showed promising results.

Supervised machine learning-based medical image computing applications necessitate expert label curation, while unlabelled image data might be relatively abundant. Active learning methods aim to prioritise a subset of available image data for expert annotation, for label-efficient model training. We develop a controller neural network that measures priority of images in a sequence of batches, as in batch-mode active learning, for multi-class segmentation tasks. The controller is optimised by rewarding positive task-specific performance gain, within a Markov decision process (MDP) environment that also optimises the task predictor. In this work, the task predictor is a segmentation network. A meta-reinforcement learning algorithm is proposed with multiple MDPs, such that the pre-trained controller can be adapted to a new MDP that contains data from different institutes and/or requires segmentation of different organs or structures within the abdomen. We present experimental results using multiple CT datasets from more than one thousand patients, with segmentation tasks of nine different abdominal organs, to demonstrate the efficacy of the learnt prioritisation controller function and its cross-institute and cross-organ adaptability. We show that the proposed adaptable prioritisation metric yields converging segmentation accuracy for the novel class of kidney, unseen in training, using between approximately 40\% to 60\% of labels otherwise required with other heuristic or random prioritisation metrics. For clinical datasets of limited size, the proposed adaptable prioritisation offers a performance improvement of 22.6\% and 10.2\% in Dice score, for tasks of kidney and liver vessel segmentation, respectively, compared to random prioritisation and alternative active sampling strategies.

Image quality assessment (IQA) forms a natural and often straightforward undertaking for humans, yet effective automation of the task remains highly challenging. Recent metrics from the deep learning community commonly compare image pairs during training to improve upon traditional metrics such as PSNR or SSIM. However, current comparisons ignore the fact that image content affects quality assessment as comparisons only occur between images of similar content. This restricts the diversity and number of image pairs that the model is exposed to during training. In this paper, we strive to enrich these comparisons with content diversity. Firstly, we relax comparison constraints, and compare pairs of images with differing content. This increases the variety of available comparisons. Secondly, we introduce listwise comparisons to provide a holistic view to the model. By including differentiable regularizers, derived from correlation coefficients, models can better adjust predicted scores relative to one another. Evaluation on multiple benchmarks, covering a wide range of distortions and image content, shows the effectiveness of our learning scheme for training image quality assessment models.

Parameter-efficient fine-tuning (PEFT) methods can adapt large language models to downstream tasks by training a small amount of newly added parameters. In multi-task settings, PEFT adapters typically train on each task independently, inhibiting transfer across tasks, or on the concatenation of all tasks, which can lead to negative interference. To address this, Polytropon (Ponti et al.) jointly learns an inventory of PEFT adapters and a routing function to share variable-size sets of adapters across tasks. Subsequently, adapters can be re-combined and fine-tuned on novel tasks even with limited data. In this paper, we investigate to what extent the ability to control which adapters are active for each task leads to sample-efficient generalization. Thus, we propose less expressive variants where we perform weighted averaging of the adapters before few-shot adaptation (Poly-mu) instead of learning a routing function. Moreover, we introduce more expressive variants where finer-grained task-adapter allocation is learned through a multi-head routing function (Poly-S). We test these variants on three separate benchmarks for multi-task learning. We find that Poly-S achieves gains on all three (up to 5.3 points on average) over strong baselines, while incurring a negligible additional cost in parameter count. In particular, we find that instruction tuning, where models are fully fine-tuned on natural language instructions for each task, is inferior to modular methods such as Polytropon and our proposed variants.

To analyze this characteristic of vulnerability, we developed an automated deep learning method for detecting microvessels in intravascular optical coherence tomography (IVOCT) images. A total of 8,403 IVOCT image frames from 85 lesions and 37 normal segments were analyzed. Manual annotation was done using a dedicated software (OCTOPUS) previously developed by our group. Data augmentation in the polar (r,{\theta}) domain was applied to raw IVOCT images to ensure that microvessels appear at all possible angles. Pre-processing methods included guidewire/shadow detection, lumen segmentation, pixel shifting, and noise reduction. DeepLab v3+ was used to segment microvessel candidates. A bounding box on each candidate was classified as either microvessel or non-microvessel using a shallow convolutional neural network. For better classification, we used data augmentation (i.e., angle rotation) on bounding boxes with a microvessel during network training. Data augmentation and pre-processing steps improved microvessel segmentation performance significantly, yielding a method with Dice of 0.71+/-0.10 and pixel-wise sensitivity/specificity of 87.7+/-6.6%/99.8+/-0.1%. The network for classifying microvessels from candidates performed exceptionally well, with sensitivity of 99.5+/-0.3%, specificity of 98.8+/-1.0%, and accuracy of 99.1+/-0.5%. The classification step eliminated the majority of residual false positives, and the Dice coefficient increased from 0.71 to 0.73. In addition, our method produced 698 image frames with microvessels present, compared to 730 from manual analysis, representing a 4.4% difference. When compared to the manual method, the automated method improved microvessel continuity, implying improved segmentation performance. The method will be useful for research purposes as well as potential future treatment planning.

复杂的伤口通常会面临部分或完全损失皮肤厚度，从而通过次要意图愈合。它们可以是急性或慢性的，可以发现感染，缺血和组织坏死以及与全身性疾病的关联。全球研究机构报告了无数案件，最终涉及严重的公共卫生问题，因为它们涉及人力资源（例如医师和医疗保健专业人员），并对生活质量产生负面影响。本文提出了一个新的数据库，用于自动将复杂伤口自动分类为五个类别，即非缠绕区域，肉芽，纤维蛋白样组织和干性坏死，血肿。这些图像包括由压力，血管溃疡，糖尿病，燃烧和手术干预后的并发症引起的复杂伤口的不同情况。该数据集（称为ComplexWoundDB）是独一无二的，因为它可以从野外获得的27美元图像中的像素级分类，即在患者的房屋中收集图像，并由四名卫生专业人员标记。用不同的机器学习技术进行的进一步实验证明了解决计算机辅助复杂伤口组织分类问题的挑战。手稿阐明了该地区未来的方向，在文献中广泛使用的其他数据库中进行了详细比较。